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The capacity to produce NO is reduced, and the vascular musculature constricts and blood pressure can be elevated

doi: 10.1038/s41581-020-00367-2

Although, both ND- and D-hpCAFs were maintained in culture in the same condition, the characterization of their features sustains the observation that also pancreatic stromal compartment is able to retain a metabolic memory of dysmetabolism [21, 69]

Some clinical and preclinical studies have demonstrated that the contribution to cardiovascular protection of GLP-1 RAs is mainly ascribed to its modest reduction of blood pressure [33], correction of dyslipidemia [34], improvement of microvascular function [35, 36], and anti-oxidization or anti-inflammation [1, 37]